As pioneers in omics in Fontan research, we’re transforming patient care through breakthroughs in science. Each publication below marks a milestone in understanding Fontan circulation at its most fundamental level. Our consortium’s work reveals the complex interplay of metabolic and cellular processes that shape patient outcomes. Browse our findings – each entry includes both the scientific paper and its practical implications for future therapeutic strategies.
Phase A (20 patients + 20 controls)
[Research – Lipidomics] Targeted metabolomic analysis of serum phospholipid and acylcarnitine in the adult Fontan patient with a dominant left ventricle (April 2019)
Michel M, Dubowy KO, Zlamy M, Karall D, Adam MG, Entenmann A, Keller MA, Koch J, Odri Komazec I, Geiger R, Salvador C, Niederwanger C, Müller U, Scholl-Bürgi S, Laser KT. T
Ther Adv Chronic Dis. 2020 Apr 27:11:2040622320916031.
doi: 10.1177/2040622320916031
[Research – Metabolomics] Targeted metabolomic analysis of serum amino acids in the adult Fontan patient with a dominant left ventricle (June 2019)
Michel M, Dubowy KO, Entenmann A, Karall D, Adam MG, Zlamy M, Odri Komazec I, Geiger R, Niederwanger C, Salvador C, Müller U, Laser KT, Scholl-Bürgi S
Sci Rep. 2020 Jun 2;10(1):8930.
doi: 10.1038/s41598-020-65852-x.
[Research – Omics methodology] Method comparison of HPLC-ninhydrin-photometry and UHPLC-PITC-tandem mass spectrometry for serum amino acid analyses in patients with complex congenital heart disease and controls (December 2020)
Michel M, Salvador C, Wiedemair V, Adam MG, Laser KT, Dubowy KO, Entenmann A, Karall D, Geiger R, Zlamy M, Scholl-Bürgi S.
Metabolomics. 2020 Dec 15;16(12):128.
doi: 10.1007/s11306-020-01741-8.
[Research – Omics methodology] Metabolomics and random forests in patients with complex congenital heart disease (October 2022)
Michel M, Laser KT, Dubowy KO, Scholl-Bürgi S, Michel E.
Front Cardiovasc Med. 2022 Oct 5;9:994068.
doi: 10.3389/fcvm.2022.994068.
[Review – Cardiac metabolism] Comparative Metabolomics in Single Ventricle Patients after Fontan Palliation: A Strong Case for a Targeted Metabolic Therapy. (August 2023)
Renaud D, Scholl-Bürgi S, Karall D, Michel M.
Metabolites. 2023 Aug 9;13(8):932.
doi: 10.3390/metabo13080932.
[Research – Proteomics] Altered Serum Proteins Suggest Inflammation, Fibrogenesis and Angiogenesis in Adult Patients with a Fontan Circulation. (May 2024)
Michel M, Renaud D, Schmidt R, Einkemmer M, Laser LV, Michel E, Dubowy KO, Karall D, Laser KT, Scholl-Bürgi S.
Int J Mol Sci. 2024 May 16;25(10):5416.
doi: 10.3390/ijms25105416.
Related works:
[Research – Imaging] Two-dimensional global longitudinal strain rate is a preload independent index of systemic right ventricular contractility in hypoplastic left heart syndrome patients after Fontan operation (November 2014)
Schlangen J, Petko C, Hansen JH, Michel M, Hart C, Uebing A, Fischer G, Becker K, Kramer HH.
Circ Cardiovasc Imaging. 2014 Nov;7(6):880-6.
doi: 10.1161/CIRCIMAGING.114.002110.
[Research] Decline of Systolic and Diastolic 2D Strain Rate During Follow-Up of HLHS Patients After Fontan Palliation (October 2016)
Michel M, Logoteta J, Entenmann A, Hansen JH, Voges I, Kramer HH, Petko C.
Pediatr Cardiol. 2016 Oct;37(7):1250-7.
doi: 10.1007/s00246-016-1424-5.
[Review] Impact of the Fontan Operation on Organ Systems (2019)
Miriam Michel, Manuela Zlamy, Andreas Entenmann, Karin Pichler, Sabine Scholl-Bürgi, Daniela Karall, Ralf Geiger, Christina Salvador, Christian Niederwanger, Hideo Ohuchi
Cardiovasc Hematol Disord Drug Targets
doi: 10.2174/1871529X19666190211165124
[Research – Metabolomics] Amino Acid and Phospholipid Metabolism as an Indicator of Inflammation and Subtle Cardiomyopathy in Patients with Marfan Syndrome (November 2021)
Bartenbach, L.; Karall, T.; Koch, J.; Keller, M.A.; Oberacher, H.; Scholl-Bürgi, S.; Karall, D.; Oemer, G.; Baumgartner, D.; Meinel, K.; et al.
Metabolites. 2021 Nov 27;11(12):805.
doi: 10.3390/metabo11120805
[Research] Influence of Respiration on Collateral Flow in the Fontan Population Using Real-time Phase-contrast Cardiovascular Magnetic Resonance: Collateral Flow Does Not Protect the Ventricle From Volume Deficiency and Diastolic Dysfunction (September 2023)
Blessing M, Körperich H, Barth P, Michel M, Dubowy O, Forreiter S, Laser KT.
J Thorac Imaging 2023 Sep 1;38(5):W64-W74.
doi: 10.1097/RTI.0000000000000684
[Review – Micronutrition] Potential Drug-Nutrient Interactions of 45 Vitamins, Minerals, Trace Elements, and Associated Dietary Compounds with Acetylsalicylic Acid and Warfarin-A Review of the Literature. (March 2024)
Renaud D, Höller A, Michel M.
Nutrients. 2024 Mar 26;16(7):950.
doi: 10.3390/nu16070950.
[Review – Metabolic therapy] Ketogenic diets in patients with inherited metabolic disorders (July 2015)
Scholl-Bürgi S, Höller A, Pichler K, Michel M, Haberlandt E, Karall D.
J Inherit Metab Dis. 2015 Jul;38(4):765-73.
doi: 10.1007/s10545-015-9872-2.