Reimagining the fundamentals – “Coming back to the blackboard”

  • Hypothesis: a return to basic physiology and biochemistry is key to address the unique challenges in Fontan circulation.
  • Primary aim: to develop mechanistic approaches to comprehend  altered core physiological and biological processes in patients with a Fontan circulation.
  • Secondary aim: to reveal links between small molecule analytes on biochemistry basis, on transcriptomic and genomic basis that drive Fontan-related comorbidities and circulatory failure.